TLR signaling that induces weak inflammatory response and SHIP1 enhances osteogenic functions

Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells

Objective(s): Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic differentiation. Materials and Methods: Annexin V-FITC assay and MTT assay ...

DOCK 8 Functions as an Adaptor that Links TLR – MyD 88 Signaling to B

DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and CD27+ memory B cells were severely reduced in DOCK8-deficient 15H.H.J. and D.R.M. contributed equally to this work. AUTHOR CONTRIBUTIONS H.H.J., D.R.M., E.J, M.J.M., N.R., A.B., I.R., H.B., and M.R. performed the experiments. L.S., S.B, R.W., G.D., M.D., W.A., I.B., S.B., N.K., H.O., A....

DOCK 8 Functions as an Adaptor that Links TLR – MyD 88 Signaling to B Cell

DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and CD27+ memory B cells were severely reduced in DOCK8-deficient 15H.H.J. and D.R.M. contributed equally to this work. AUTHOR CONTRIBUTIONS H.H.J., D.R.M., E.J, M.J.M., N.R., A.B., I.R., H.B., and M.R. performed the experiments. L.S., S.B, R.W., G.D., M.D., W.A., I.B., S.B., N.K., H.O., A....

Editorial: Cross-Talk Mechanisms of Wnt/Beta-Catenin Signaling Components with TLR-Activated Signaling Molecules in the Inflammatory Response

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed in microglia in the brain. A soluble form of TREM2 (sTREM2) derived from proteolytic cleavage of the cell surface receptor is increased in the preclinical stages of AD and positively correlates with the amounts of total and phosphorylated tau in the cerebrospinal fluid. However, the physiological and...